3.5 out of 124 reviews READ REVIEWS

Beauty Bioscience R45 The Reversal 3-Phase System

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Product Description

Beauty Bioscience R45 The Reversal 3-Phase System

What It Is
An advanced multi-phase system that helps reduce the appearance of fine lines and wrinkles.

What You Get

  • .17 fl. oz. R45: The Reversal Regeneration Complex Phase 1A
  • .17 fl. oz. R45: The Reversal GFS Serum Phase 1B
  • .17 fl. oz. R45: The Reversal Regeneration Complex Phase 2A
  • .17 fl. oz. R45: The Reversal GFS Serum Phase 2B
  • .17 fl. oz. R45: The Reversal Regeneration Complex Phase 3A
  • .17 fl. oz. R45: The Reversal GFS Serum Phase 3B 

What It Does

  • Proprietary mixture of Vitamin A and peptides helps improve the appearance of wrinkles, skin tone evenness, pores and skin spots
  • Wrinkle-filler alternative; helps plump wrinkles
  • Optimizes the epidural layers of the skin and assists with natural cell turnover
  • Titration therapy helps mitigate the traditional side effects associated with highly active Vitamin A products
  • Concentration of ingredients increases from Phase 1 through Phase 3

Consumer Perception Survey

  • Out of 30 participants, 100% reported their skin looked better after 45 days.
  • Out of 30 participants, 100% would recommend this product to a friend.
  • Out of 30 participants, 95% reported a visible change in their skin.
  • After using RetinoSyn-45, 1 out of 3 participants moved to the 98% percentile for wrinkles for their age group and like demographics, which means they had less wrinkles than 98% of over a million like women in the Visia database.
  • Participants age 40 and over saw a 51.6% improvement in the appearance of wrinkles as determined by the Visia database of over a million women.
  • Women under 40 had a 20% improvement in skin tone evenness based on the Visia database of over a million women.
  • As determined by VISIA analysis, clinical trial participants saw a 49% reduction in the appearance of wrinkles.
  • Every participant had a positive response in one or more testing categories.

How to Use

  • Use nightly for 45 days, twice yearly.
  • Phase 1 will be used for two weeks, Phase 2 for the following 2 weeks and Phase 3 for the following 2 weeks.
  • Order of application:
    - Cleanse with a gentle cleanser
    - Use a pump of A and a pump of B on Phase 1 nightly.
    - Once 2 weeks have elapsed, switch over to Phase 2 and repeat process until finished with Phase 3.
  • You have the option to continue on to Phase 4 (sold separately) or stop at Phase 3.
  • After a nightly R45 application it is recommended that you moisturize with a serum and/or a non-anti-aging moisturizer(sold separately).
  • Use once nightly for the time frame above.
  • Recommended for use twice yearly but can be used more often if desired.

Made in USA

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Beauty Bioscience R45 The Reversal 3-Phase System
124 reviews 3.5 out of 5

Review Breakdown

5 Star
42.74% 53
4 Star
12.1% 15
3 Star
15.32% 19
2 Star
9.68% 12
1 Star
20.16% 25
Would recommend to a friend
  • bandykat, KY

    Finally see results!!!

    This is the first product I've tried that delivers what it advertises. It took about 3 weeks but I can honestly say my skin looks brighter and more youthful. Lines around my mouth and even sagging has diminished. Undereye darkness has decreased and I dont look tired all the time. I can't wait to see results after completing all three phases. I am 58.I use with bioscience micro-needling

    Was this review helpful? 0 out of 1 found this review helpful
  • productchick, WA

    It WORKS!!!

    This system really works. I have 40 year old skin, my biggest issues are texture, fine lines and uneven skin tone. Using this set has actually transformed my skin and it looks so much healthier. I have R45 phase 4 to start next. I will never be without and its part of my nightly skin care routine. its simple and effective.

    Was this review helpful? 1 out of 1 found this review helpful
  • Oldgoatie, NV

    Love the face

    Love this system for your face. It has made a big difference in .y lines, but helped the texture the most. I will be using this for ever.

    Was this review helpful? 1 out of 1 found this review helpful
  • 2222, WV

    Just what My Skin Needed

    So I have tried an spent hundreds of dollars on cosmetics an my husband always said you spend all that money an it hasnt done anything but he was right so last resort I bought this from Bioscience an started seeing results but didnt think husband an this eve he said your skin is looking glowing an soft Wow first time ever ! Also my lines are disaperring an Im at end of no 2 so cant wait to see what no 3 will do So excited finally something works!!!

    Was this review helpful? 4 out of 4 found this review helpful
  • kasanchz, WA


    I'm only 5 days in to this 45 day treatment and I can already see a difference in my skin! I also use my glo pro before I apply and literally my skin just absorbs this stuff like a sponge! I cant wait to see my ultimate results at 45 days! Should have taken a comparison pic.

    Was this review helpful? 3 out of 3 found this review helpful

About The Brand


After spending years helping to develop cutting-edge beauty technology and products for prominent cosmetics companies, Jamie O'Banion and Dr. Terry James created new patented technology so exceptional they decided to launch it themselves. Beauty Bioscience is all fact and no fluff, delivering real results with carefully edited products that actually work, from the award-winning GloPRO® tool to cult-following topicals. BeautyBio babes around the world celebrate a new era of empowered confidence inside and out. The results truly speak for themselves!